Information on the prescription status of this product may be found on the label / outer package. If you need more information about your animal’s medical condition or treatment, contact your veterinarian. Ingestion of mineral oil may cause laxative effect, nausea, dehydration or lipid pneumonia. Select one or more newsletters to continue.
The control group received the vehicle in both ears at the clinical dose given five times per day. Copyright @ 2009 Intervet Inc., a subsidiary of Merck & Co. Inc Madison, NJ 07940 USA, (Orbifloxacin, Mometasone Furoate Monohydrate andPosaconazole, Suspension), Set id: f64232d7-e904-45d5-924d-07850f9c3e3d, Percent of Dogs Showing Improvement in Clinical Signs of Otitis Externa, orbifloxacin, mometasone furoate, and posaconazole suspension. INDICATIONS: POSATEX® Otic Suspension is indicated for the treatment of otitis externa in dogs associated with susceptible strains of yeast (Malassezia pachydermatis) and bacteria (coagulase positive staphylococci, Pseudomonas aeruginosa, and Enterococcus faecalis). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
Most of the absorption occurred in the first few days after administration. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Systemic absorption of the active ingredients was determined in single-dose radiolabelled studies with 14C-orbifloxacin, 3H-mometasone furoate, and 14C-posaconazole contained within the POSATEX® Otic Suspension formulation and placed into the ear canals of normal beagle dogs. The control group received the vehicle in both ears at the clinical dose given five times per day. HOW SUPPLIED: POSATEX® Otic Suspension is available in 7.5 g, 15 g, and 30 g plastic bottles. %PDF-1.4 %���� The mechanism by which triazoles exert fungicidal action involves the selective inhibition of the enzyme lanosterol a C14 demethylase (a microsomal cytochrome P-450- dependent enzyme) involved in ergosterol biosynthesis in yeasts and filamentous fungi.
Erythema was noted in all groups. Of the 160 dogs evaluated for effectiveness, 122 … Orbifloxacin is an antibiotic that belongs to the group fluoroquinolones. Posaconazole: Posaconazole is a broad-spectrum triazole antifungal agent. The systemic administration of quinolones has been shown to produce cartilage erosions of weight bearing joints and other signs of arthropathy in immature animals of various species. We comply with the HONcode standard for trustworthy health information -, Warnings and cautions for Posatex Otic Suspension, Direction and dosage information for Posatex Otic Suspension.
One hundred and ninety one dogs with naturally occurring clinical otitis externa associated with both yeast and bacteria were randomly allocated to either POSATEX® Otic Suspension or placebo ointment.
Posatex Treatment of acute otitis externa and acute exacerbations of recurrent otitis externa, associated with bacteria susceptible to orbifloxacin and fungi susceptible to posaconazole, in particular Malassezia pachydermatis. They treat animal-only conditions and those also found in humans, and come in forms and dosages specifically for pets. The Committee for Medicinal Products for Veterinary Use (CVMP) concluded that the benefits of Posatex exceed its risks for the treatment of acute otitis externa and acute exacerbations of recurrent otitis externa in dogs and recommended that Posatex be given a marketing authorisation. instill 4 drops of POSATEX® Otic Suspension once daily into the ear canal. Generic Name: orbifloxacin, mometasone furoate, and posaconazole otic Suspension orbifloxacin, mometasone furoate, and posaconazole suspension, We comply with the HONcode standard for trustworthy health information -. The mechanism by which triazoles exert fungicidal action involves the selective inhibition of the enzyme lanosterol a C14 demethylase (a microsomal cytochrome P-450- dependent enzyme) involved in ergosterol biosynthesis in yeasts and filamentous fungi. HOW SUPPLIED: POSATEX® Otic Suspension is available in 7.5 g, 15 g, and 30 g plastic bottles.
DOSAGE AND ADMINISTRATION: Shake well before use. Immediately discontinue use of POSATEX™ Otic Suspension if hearing loss is observed during treatment (see ADVERSE REACTIONS). extensively used in clinical settings without adverse effects in humans. Assessment of effectiveness was based on improvement in clinical signs at re-evaluation 2-7 days following administration of the last dose. Aural pain, swelling, or heat were each noted in 3 separate dogs in the 5× group.
Compared to the placebo, a significant percent of dogs treated with POSATEX® Otic Suspension showed improvement in clinical signs (discomfort, erythema, and swelling) caused by otitis externa associated with one or more of the following organisms: Malassezia pachydermatis, coagulase positive staphylococci, Pseudomonas aeruginosa, and Enterococcus faecalis. Treatments were administered once daily for 7 consecutive days.
Inflammation can increase the percutaneous absorption of drugs. Do not use in dogs with known tympanic perforation (see PRECAUTIONS).
The bactericidal action of fluoroquinolones is concentration-dependent and results from interference with bacterial DNA gyrase and topoisomerase IV. By blocking DNA gyrase, orbifloxacin prevents the bacteria from making DNA and stops them making proteins and growing, resulting in their death.
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42 0 obj <> endobj Ear infections in dogs can be caused by bacteria or fungi. If accidental skin contact occurs, wash immediately with lots of water.